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Protein Coding Gene : Ero1b endoplasmic reticulum oxidoreductase 1 beta
Primary Identifier  MGI:1914725 Organism  mouse, laboratory
Chromosome  13 NCBI Gene Number  67475
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0)

Enables protein-disulfide reductase activity. Involved in insulin processing. Acts upstream of or within several processes, including cell redox homeostasis; glucose homeostasis; and protein maturation by protein folding. Located in membrane. Is active in endoplasmic reticulum lumen. Is expressed in heart and hindlimb joint. Orthologous to human ERO1B (endoplasmic reticulum oxidoreductase 1 beta).
PHENOTYPE: Mice homozygous for a gene trap allele exhibit increased circulating glucose levels, decreased pancreas insulin levels, and disorganized islets. [provided by MGI curators]
  • synonyms:
  • MGI:1920689,
  • RIKEN cDNA 1300013B24 gene,
  • AI447560,
  • 1700065B09Rik,
  • Ero1lb,
  • RIKEN cDNA 1700065B09 gene,
  • Ero1b,
  • expressed sequence AI447560,
  • ERO1-like beta (S. cerevisiae),
  • MGI:2145237,
  • endoplasmic reticulum oxidoreductase 1 beta,
  • 1300013B24Rik
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