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Protein Coding Gene : Tmem178 transmembrane protein 178

Primary Identifier  MGI:1915277 Organism  mouse, laboratory
Chromosome  17 NCBI Gene Number  68027
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0)

Involved in negative regulation of osteoclast differentiation and regulation of cytosolic calcium ion concentration. Located in endoplasmic reticulum membrane. Is expressed in brain and ventral grey horn. Orthologous to human TMEM178A (transmembrane protein 178A).
PHENOTYPE: Mice homozygous for a knock-out allele exhibit decreased bone mass, osteopenia, and increased osteoclast differentiation under basal and inflammatory conditions. [provided by MGI curators]
  • synonyms:
  • Tmem178,
  • 2810417M05Rik,
  • transmembrane protein 178,
  • RIKEN cDNA 2810417M05 gene

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Canonical gene --> Transcripts in specific strains.

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