Primary Identifier | MGI:1856078 | Allele Type | Spontaneous |
Attribute String | Null/knockout | Gene | Scn8a |
Inheritance Mode | Recessive | Strain of Origin | PCT |
Is Recombinase | false | Is Wild Type | false |
molecularNote | The mutation was identified as a small LINE element insertion into exon 2 of the Scn8a gene. This results in exon skipping which is influenced by the AT-AC splice sites in intron 2, and generates a very short inactive protein. This allele is a predicted null. |