| Primary Identifier | MGI:1344351 | Organism | mouse, laboratory |
| Chromosome | 7 | NCBI Gene Number | 23859 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.0.0) A structural constituent of postsynaptic density. Involved in several processes, including axo-dendritic protein transport; clustering of voltage-gated potassium channels; and neurotransmitter receptor localization to postsynaptic specialization membrane. Acts upstream of or within chemical synaptic transmission; maintenance of postsynaptic density structure; and sensory perception of pain. Located in several cellular components, including juxtaparanode region of axon; postsynaptic membrane; and synaptic vesicle membrane. Is active in axon initial segment and glutamatergic synapse. Is expressed in jaw bone; nervous system; and retina. Orthologous to human DLG2 (discs large MAGUK scaffold protein 2). PHENOTYPE: Mice homozygous for a knock-out allele display lower surface expression of NMDA receptor (NMDAR) subunits NR2A and NR2B in dorsal horn neurons and significantly reduced NMDAR-mediated excitatory synaptic currents and NMDAR-dependent persistent inflammatory or nerve injury-induced neuropathic pain. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
