| First Author | Elgar G | Year | 1996 |
| Journal | Trends Genet | Volume | 12 |
| Issue | 4 | Pages | 145-50 |
| PubMed ID | 8901419 | Mgi Jnum | J:32195 |
| Mgi Id | MGI:79769 | Doi | 10.1016/0168-9525(96)10018-4 |
| Citation | Elgar G, et al. (1996) Small is beautiful: comparative genomics with the pufferfish (Fugu rubripes). Trends Genet 12(4):145-50 |
| abstractText | As the Human Genome Project advances, it is clear that the emphasis will switch from accumulation of data to their interpretation. Comparative genomics provides a powerful way in which to analyse sequence data. Indeed, there is already a long list of 'model' organisms, which allow comparative analyses in a variety of ways. The very small vertebrate genome of the pufferfish provides a simple and economical way of comparing sequence data from mammals and fish, representing a large evolutionary divergence and so permitting the identification of essential elements that are still present in both species. These elements include genes and the associated machinery that controls their expression; elements that, in many cases, have survived the test of time. |
