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Publication : Small is beautiful: comparative genomics with the pufferfish (Fugu rubripes).

First Author  Elgar G Year  1996
Journal  Trends Genet Volume  12
Issue  4 Pages  145-50
PubMed ID  8901419 Mgi Jnum  J:32195
Mgi Id  MGI:79769 Doi  10.1016/0168-9525(96)10018-4
Citation  Elgar G, et al. (1996) Small is beautiful: comparative genomics with the pufferfish (Fugu rubripes). Trends Genet 12(4):145-50
abstractText  As the Human Genome Project advances, it is clear that the emphasis will switch from accumulation of data to their interpretation. Comparative genomics provides a powerful way in which to analyse sequence data. Indeed, there is already a long list of 'model' organisms, which allow comparative analyses in a variety of ways. The very small vertebrate genome of the pufferfish provides a simple and economical way of comparing sequence data from mammals and fish, representing a large evolutionary divergence and so permitting the identification of essential elements that are still present in both species. These elements include genes and the associated machinery that controls their expression; elements that, in many cases, have survived the test of time.
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