| First Author | Setou M | Year | 2000 |
| Journal | Science | Volume | 288 |
| Issue | 5472 | Pages | 1796-802 |
| PubMed ID | 10846156 | Mgi Jnum | J:62660 |
| Mgi Id | MGI:1859430 | Doi | 10.1126/science.288.5472.1796 |
| Citation | Setou M, et al. (2000) Kinesin superfamily motor protein KIF17 and mLin-10 in NMDA receptor-containing vesicle transport. Science 288(5472):1796-802 |
| abstractText | Experiments with vesicles containing N-methyl-D-aspartate (NMDA) receptor 2B (NR2B subunit) show that they are transported along microtubules by KIF17, a neuron-specific molecular motor in neuronal dendrites. Selective transport is accomplished by direct interaction of the KIF17 tail with a PDZ domain of mLin-10 (Mint1/X11), which is a constituent of a large protein complex including mLin-2 (CASK), mLin-7 (MALS/Velis), and the NR2B subunit. This interaction, specific for a neurotransmitter receptor critically important for plasticity in the postsynaptic terminal, may be a regulatory point for synaptic plasticity and neuronal morphogenesis. |
