| First Author | Kümin A | Year | 2006 |
| Journal | Am J Pathol | Volume | 169 |
| Issue | 4 | Pages | 1194-205 |
| PubMed ID | 17003478 | Mgi Jnum | J:113375 |
| Mgi Id | MGI:3665529 | Doi | 10.2353/ajpath.2006.060119 |
| Citation | Kumin A, et al. (2006) Peroxiredoxin 6 is a potent cytoprotective enzyme in the epidermis. Am J Pathol 169(4):1194-205 |
| abstractText | Peroxiredoxin 6 is an enzyme that detoxifies hydrogen peroxide and various organic peroxides. In previous studies we found strongly increased expression of peroxiredoxin 6 in the hyperproliferative epidermis of wounded and psoriatic skin, suggesting a role of this enzyme in epidermal homeostasis. To address this question, we generated transgenic mice overexpressing peroxiredoxin 6 in the epidermis. Cultured keratinocytes from transgenic mice showed enhanced resistance to the toxicity of various agents that induce oxidative stress. However, overexpression of peroxiredoxin 6 did not affect skin morphogenesis or homeostasis. On skin injury, enhancement of wound closure was observed in aged animals. Most importantly, peroxiredoxin 6 overexpression strongly reduced the number of apoptotic cells after UVA or UVB irradiation. These findings demonstrate that peroxiredoxin 6 protects keratinocytes from cell death induced by reactive oxygen species in vitro and in vivo, suggesting that activation of this enzyme could be a novel strategy for skin protection under stress conditions. |
