| First Author | Osada T | Year | 2001 |
| Journal | Mol Endocrinol | Volume | 15 |
| Issue | 6 | Pages | 882-93 |
| PubMed ID | 11376108 | Mgi Jnum | J:69613 |
| Mgi Id | MGI:1934995 | Doi | 10.1210/mend.15.6.0644 |
| Citation | Osada T, et al. (2001) Puromycin-sensitive aminopeptidase is essential for the maternal recognition of pregnancy in mice. Mol Endocrinol 15(6):882-93 |
| abstractText | Maternal recognition of pregnancy in rodents requires semicircadian surges of hypophyseal PRL secretion during early gestation, which are required for the formation of the corpus luteum of pregnancy (CLP). Here we show that puromycin-sensitive aminopeptidase (Psa)-deficient mice display female infertility that results from impaired formation of CLP. Transplantation of mutant ovaries into normal females restored fertility but not vice versa. Psa-deficient females revealed no semicircadian surges of PRL induced after mating stimuli. Pregnancy in the mutant females was restored by grafting intact pituitaries to elevate circulating levels of PRL. Psa is thus required for the appearance of the semicircadian surges of PRL secretion that are crucial for maintaining pregnancy in rodents. |
