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Protein Coding Gene : Mettl13 methyltransferase 13, eEF1A lysine and N-terminal methyltransferase

Primary Identifier  MGI:1918699 Organism  mouse, laboratory
Chromosome  1 NCBI Gene Number  71449
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.0.0)

Predicted to enable protein-lysine N-methyltransferase activity. Predicted to be involved in negative regulation of cell cycle G1/S phase transition and negative regulation of transcription by RNA polymerase II. Predicted to act upstream of or within methylation. Located in mitochondrion and nucleus. Is expressed in axial musculature and submandibular gland primordium. Orthologous to human METTL13 (methyltransferase 13, eEF1A N-terminus and K55).
PHENOTYPE: Mice heterozygous for a null allele exhibit infertility, bilateral cryptorchism, abnormal spermatogenesis, and increased Leydig cell number. [provided by MGI curators]
  • synonyms:
  • EEF1A lysine and N-terminal methyltransferase,
  • Eef1aknmt,
  • methyltransferase 13, eEF1A lysine and N-terminal methyltransferase,
  • Mettl13,
  • 5630401D24Rik,
  • methyltransferase like 13,
  • RIKEN cDNA 5630401D24 gene

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2 Involved In Mutations

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Canonical gene --> Transcripts in specific strains.

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