| Primary Identifier | MGI:87991 | Organism | mouse, laboratory |
| Chromosome | 5 | NCBI Gene Number | 11657 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0) Predicted to enable several functions, including anion binding activity; toxic substance binding activity; and zinc ion binding activity. Predicted to contribute to oxygen binding activity. Predicted to be involved in cellular response to calcium ion starvation; negative regulation of mitochondrial depolarization; and positive regulation of circadian sleep/wake cycle, non-REM sleep. Located in cytoplasm and extracellular space. Is expressed in several structures, including alimentary system; brain; extraembryonic component; liver and biliary system; and trunk musculature. Human ortholog(s) of this gene implicated in several diseases, including blood protein disease; hepatobiliary system cancer (multiple); hyperthyroxinemia; middle cerebral artery infarction; and psoriasis. Orthologous to human ALB (albumin). PHENOTYPE: Mice homozygous for a TALEN-mediated deletion exhibit analbuminemia but appear healthy and grossly normal and breed normally. Mice heterozygotes for an ENU-induced point mutation have significantly reduced plasma albumin and calcium levels and significantly elevated alkaline phosphatase activity. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
