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Type  disruption phenotype Description  Mice are normal but males are sterile. Male sterility is due to defects in sperm motility unability to fertilize intact eggs. In mice lacking Catsper1, the sperm lacks CatSper2, while in mice lacking CatSper1, the sperm lacks CatSper1, suggesting that stable expression of CatSper1 requires CatSper2 and vice versa.