Primary Identifier | MGI:1349462 | Organism | mouse, laboratory |
Chromosome | 9 | NCBI Gene Number | 74153 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.0.0) Enables ISG15 activating enzyme activity. Acts upstream of or within ISG15-protein conjugation and modification-dependent protein catabolic process. Predicted to be active in cytoplasm. Is expressed in liver lobe and thymus primordium. Orthologous to human UBA7 (ubiquitin like modifier activating enzyme 7). PHENOTYPE: Homozygous null mice lacking ISG15 conjugation but not free ISG15 are healthy and fertile and exhibit normal antiviral responses against vesicular stomatitis virus and lymphocytic choriomeningitis virus infection. Bone-derived macrophages from mutant mice display normal responses to IFN treatment. [provided by MGI curators] |