| Primary Identifier | MGI:95808 | Organism | mouse, laboratory |
| Chromosome | 11 | NCBI Gene Number | 14799 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0) Enables AMPA glutamate receptor activity; neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration; and transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential. Involved in several processes, including long-term memory; receptor internalization; and synapse assembly. Acts upstream of or within cellular response to ammonium ion; chemical synaptic transmission; and long-term synaptic depression. Located in several cellular components, including neuron spine; perisynaptic space; and postsynaptic density membrane. Part of AMPA glutamate receptor complex. Is active in dendritic spine membrane and excitatory synapse. Is expressed in several structures, including alimentary system; brain; cardiovascular system; genitourinary system; and sensory organ. Used to study schizoaffective disorder. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder and autosomal recessive intellectual developmental disorder 76. Orthologous to human GRIA1 (glutamate ionotropic receptor AMPA type subunit 1). PHENOTYPE: Mice with mutations in phosphorylation sites have LTD and LTP deficits and spatial learning memory defects. Null homozygotes also show stimulus-reward learning deficits and increases locomotor activity and context-dependent sensitization to amphetamine. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
