|  Help  |  About  |  Contact Us

Allele : Cacna1c<tm1.1Wac> calcium channel, voltage-dependent, L type, alpha 1C subunit; targeted mutation 1.1, William A Catterall
Primary Identifier  MGI:5528791 Allele Type  Targeted
Gene  Cacna1c Transmission  Germline
Strain of Origin  Not Specified Is Recombinase  false
Is Wild Type  false
molecularNote  Point mutations were introduced in exon 41 to express Ala in place of Ser1700 and Thr1704 in the alpha-1 subunit of Cav1.2. The neo cassette was removed by flp mediated recombination. The total number of Cav1.2 channels are reduced by approximately 12% in myocytes from homozygous mice compared with wild-type.
  • mutations:
  • Nucleotide substitutions,
  • Insertion
  • synonyms:
  • STAA,
  • STAA
Paste the following link
Quick Links:
SummaryGenomePhenotypeOther
 
Quick Links:
SummaryGenomePhenotypeOther
 
Lists
This Allele isn't in any lists. Upload a list.

1 Feature

Trail: Allele

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

0 Carried By

0 Driven By

6 Publication categories

Trail: Allele




MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Copyright © 2017 by The Jackson Laboratory. All Rights Reserved

© 2002 - 2017 Department of Genetics, University of Cambridge, Downing Street,
Cambridge CB2 3EH, United Kingdom