| First Author | Lange R | Year | 1995 |
| Journal | DNA Cell Biol | Volume | 14 |
| Issue | 11 | Pages | 971-81 |
| PubMed ID | 7576184 | Mgi Jnum | J:29976 |
| Mgi Id | MGI:77499 | Doi | 10.1089/dna.1995.14.971 |
| Citation | Lange R, et al. (1995) Developmentally regulated mouse gene NK10 encodes a zinc finger repressor protein with differential DNA-binding domains. DNA Cell Biol 14(11):971-81 |
| abstractText | Using oligonucleotides complementary to the conserved inter-finger region of a variety of previously described zinc finger-encoding genes, a novel mouse gene was cloned and characterized. The gene is localized on chromosome 8 and comprises five exons. Its corresponding mRNA is developmentally regulated in various tissues and includes an open reading frame encoding a protein of 72,422 daltons. It shares amino-terminal homologies with human KRAB (or FPB) boxes, and contains 13 zinc fingers of the C2-H2 type. The NK10 KRAB domains exhibit repressing activity when tested in GAL4 fusion protein assays. Cloning of putative target sequences revealed that the individual domains differentially contribute to zinc-dependent target DNA binding. |
