| Primary Identifier | MGI:97535 | Organism | mouse, laboratory |
| Chromosome | 2 | NCBI Gene Number | 18610 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0) Predicted to enable neuropeptide hormone activity and opioid receptor binding activity. Predicted to be involved in chemical synaptic transmission; neuropeptide signaling pathway; and sensory perception. Predicted to act upstream of or within signal transduction. Predicted to be located in several cellular components, including Golgi apparatus; dendritic spine; and dense core granule. Predicted to be active in several cellular components, including hippocampal mossy fiber to CA3 synapse; neuronal cell body; and secretory vesicle. Is expressed in several structures, including central nervous system; oviduct; and retina. Human ortholog(s) of this gene implicated in several diseases, including alcohol dependence; alcohol use disorder; amphetamine abuse; drug dependence (multiple); and spinocerebellar ataxia type 23. Orthologous to human PDYN (prodynorphin). PHENOTYPE: Homozygotes for targeted null mutations exhibit high postnatal mortality, impaired thermoregulation, and loss of white fat. Survivors show ketosis, microvesicular fat accumulation, elevated serum lipids, and behavioral abnormalities. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
