Primary Identifier | MGI:2679683 | Organism | mouse, laboratory |
Chromosome | 5 | NCBI Gene Number | 231474 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0) Predicted to enable signaling receptor activity. Acts upstream of or within negative regulation of protein phosphorylation. Predicted to be located in Golgi apparatus. Is expressed in cerebral cortex intermediate zone and cortical plate. Orthologous to human PAQR3 (progestin and adipoQ receptor family member 3). PHENOTYPE: Targeted deletion of this gene causes faster chemical carcinogen-induced skin cell proliferation, higher epidermal thickness, increased number and size of skin papillomas, shorter tumor latency and delayed tumor regression. Heterozygotes develop tumors earlier and more frequently than control mice. [provided by MGI curators] |