| First Author | Wu X | Year | 2020 |
| Journal | Science | Volume | 369 |
| Issue | 6506 | Pages | 984-988 |
| PubMed ID | 32820125 | Mgi Jnum | J:295900 |
| Mgi Id | MGI:6456949 | Doi | 10.1126/science.aba6652 |
| Citation | Wu X, et al. (2020) SOSTDC1-producing follicular helper T cells promote regulatory follicular T cell differentiation. Science 369(6506):984-988 |
| abstractText | Germinal center (GC) responses potentiate the generation of follicular regulatory T (TFR) cells. However, the molecular cues driving TFR cell formation remain unknown. Here, we show that sclerostin domain-containing protein 1 (SOSTDC1), secreted by a subpopulation of follicular helper T (TFH) cells and T-B cell border-enriched fibroblastic reticular cells, is developmentally required for TFR cell generation. Fate tracking and transcriptome assessment in reporter mice establishes SOSTDC1-expressing TFH cells as a distinct T cell population that develops after SOSTDC1(-) TFH cells and loses the ability to help B cells for antibody production. Notably, Sostdc1 ablation in TFH cells results in substantially reduced TFR cell numbers and consequently elevated GC responses. Mechanistically, SOSTDC1 blocks the WNT-beta-catenin axis and facilitates TFR cell differentiation. |
