| Primary Identifier | IPR042238 | Type | Family |
| Short Name | Rad28/ERCC8/Ckn1/ATCSA-1 |
| description | This entry represents a group of DNA excision repair proteins, including Rad28 from budding yeasts [], Ckn1 from fission yeasts, ATCSA-1 from Arabidopsis []and ERCC8 (also known as CSA) from animals []. Ckn1 is involved in transcription-coupled nucleotide excision repair []. Human CSA is part of a E3-ubiquitin ligase (E3-ub ligase) complex and plays an important part in transcription-coupled repair (TCR)[]. In Arabidopsis, ATCSA-1 is a critical component for initiating the repair of UV-B-induced DNA lesions [].Mutations in the CSA gene cause Cockayne syndrome A (CSA), a rare disorder characterised by cutaneous sensitivity to sunlight, abnormal and slow growth, cachectic dwarfism, progeroid appearance, progressive pigmentary retinopathy and sensorineural deafness []. |
