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Publication : Lack of amyloidosis and renal disease in A strain mice.

First Author  Powers JM Year  1976
Journal  Arch Pathol Lab Med Volume  100
Issue  2 Pages  69-73
PubMed ID  946395 Mgi Jnum  J:23525
Mgi Id  MGI:71274 Citation  Powers JM, et al. (1976) Lack of amyloidosis and renal disease in A strain mice. Arch Pathol Lab Med 100(2):69-73
abstractText  Amyloid deposition in two sublines of the A strain mouse, a reputedly reliable murine model of spontaneous amyloidosis, was reevaluated using combined green polarization birefringence after Congo red staining and a fibrillar ultrastructure for amyloid identification. Both sublines were found to be devoid of amyloid at an age when the A strain mouse had been reported to have a high incidence of papillonephritis, amyloidosis, and death. This finding indicates a need for reassessment of this and other traditional models of spontaneous amyloidosis.
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