Primary Identifier | MGI:1915265 | Organism | mouse, laboratory |
Chromosome | 16 | NCBI Gene Number | 68015 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0) Predicted to enable protein kinase binding activity and unfolded protein binding activity. Predicted to be involved in several processes, including negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide; protein folding; and translational attenuation. Located in mitochondrion. Is active in cell periphery. Is expressed in several structures, including adrenal gland; cerebral cortex; gonad; metanephros epithelium; and white fat. Orthologous to human TRAP1 (TNF receptor associated protein 1). PHENOTYPE: Mice homozygous for a gene trap allele exhibit reduced body weight; liver and spleen hyperplasia; decreased chronic inflammation and tumor incidents; deregulated mitochondrial respiration; and increased oxidative stress. [provided by MGI curators] |