| Primary Identifier | MGI:5911855 | Allele Type | Targeted |
| Gene | Prdx6 | Transmission | Germline |
| Strain of Origin | C57BL/6 | Is Recombinase | false |
| Is Wild Type | false |
| molecularNote | The targeting vector is designed to insert, by site-directed mutagenesis, a point mutation (GAC to GCC) at nucleotide 419 followed by an FRT-flanked neomycin cassette downstream of exon 4. The mutation results in an alteration of the corresponding amino acid from aspartic acid to alanine (D140A) at codon 140. Flp-mediated recombination removed the FRT-flanked neo cassette. The mutation does not affect peroxidase activity, but does eliminate phospholipase A2 activity. |
