| Type | MGI:General | Description | hearts exhibit delayed recovery after low-flow ischemia hearts of fasted mutants exhibit decreased lactate production (75%) indicating depressed glucose utilization during ischemia and develop irreversible systolic and diastolic dysfunction as indicated by an increase in left ventricular end-diastolic pressure that remains elevated on reperfusion and a left ventricular developed pressure that does not recovery fully, as well as impaired ability to generate ATP during ischemia (accelerated depletion of ATP and decreased levels of ATP recovery on reperfusion) hearts of fed mutants exhibit normal left ventricular pressure during ischemia, however recovery of the left ventricular developed pressure is delayed during reperfusion and hearts exhibit a decrease (28%) in lactate production during ischemia |
