Other
11 Authors
- Li Y,
- Ye Z,
- Zeng H,
- Hitosugi T,
- Li C,
- Zhou X,
- Sun J,
- Bernlohr DA,
- Zhu X,
- Shapiro VS,
- Copland JA 3rd
| First Author | Zhou X | Year | 2021 |
| Journal | Cell Rep | Volume | 34 |
| Issue | 1 | Pages | 108601 |
| PubMed ID | 33406440 | Mgi Jnum | J:304272 |
| Mgi Id | MGI:6694821 | Doi | 10.1016/j.celrep.2020.108601 |
| Citation | Zhou X, et al. (2021) Stearoyl-CoA Desaturase-Mediated Monounsaturated Fatty Acid Availability Supports Humoral Immunity. Cell Rep 34(1):108601 |
| abstractText | Immune cells can metabolize glucose, amino acids, and fatty acids (FAs) to generate energy. The roles of different FA species and their impacts on humoral immunity remain poorly understood. Here, we report that proliferating B cells require monounsaturated FAs (MUFAs) to maintain mitochondrial metabolism and mTOR activity and to prevent excessive autophagy and endoplasmic reticulum (ER) stress. Furthermore, B cell-extrinsic stearoyl-CoA desaturase (SCD) activity generates MUFA to support early B cell development and germinal center (GC) formation in vivo during immunization and influenza infection. Thus, SCD-mediated MUFA production is critical for humoral immunity. |
