| Primary Identifier | IPR034414 | Type | Domain |
| Short Name | DND1_RRM1 |
| description | This entry represents the RNA recognition motif 1 (RRM1) of DND1, an RNA-binding protein that is essential for maintaining viable germ cells in vertebrates [, ]. It interacts with the 3'-untranslated region (3'-UTR) of multiple messenger RNAs (mRNAs) and prevents micro-RNA (miRNA) mediated repression of mRNA [, ]. For instance, DND1 binds cell cycle inhibitor, P27 (p27Kip1, CDKN1B), and cell cycle regulator and tumor suppressor, LATS2 (large tumor suppressor, homologue 2 of Drosophila) []. It helps maintain their protein expression through blocking the inhibitory function of microRNAs (miRNA) from these transcripts. DND1 may also impose another level of translational regulation to modulate expression of critical factors in embryonic stem (ES) cells. DND1 interacts specifically with apolipoprotein B editing complex 3 (APOBEC3), a multi-functional protein inhibiting retroviral replication. The DND1-APOBEC3 interaction may play a role in maintaining viability of germ cells and for preventing germ cell tumor development []. DND1 contains two conserved RNA recognition motifs (RRMs). |
