| Primary Identifier | IPR004666 | Type | Family |
| Short Name | RpS6_RimK/Lys_biosynth_LsyX |
| description | Escherichia coli RimK adds additional Glu residues to the native Glu-Glu C terminus of ribosomal protein S6. Mutation of the Glu-Glu terminus to Lys-Glu blocked addition. S6 has the C-terminal sequence Glu-Glu in few species, suggesting the homologue of rimK may have a function other than S6 modification in those species. However, most species having a member of this protein subfamily do not have an S6 homologue ending in Glu-Glu.The family of proteins found in this family include the characterised LysX from Thermus thermophilus []which is part of a well-organised lysine biosynthesis gene cluster []. LysX is believed to carry out an ATP-dependent acylation of the amino group of alpha-aminoadipate in the prokaryotic version of the fungal AAA lysine biosynthesis pathway. No species having a sequence in this family contains the elementsof the more common diaminopimelate lysine biosythesis pathway, and none has been shown to be a lysine auxotroph. These sequences have mainly recieved the name of the related enzyme, "ribosomal protein S6 modification protein RimK". RimK has been characterised in Escherichia coli, and acts by ATP-dependent condensation of S6 with glutamate residues []. |
