| First Author | Kuro-o M | Year | 1997 |
| Journal | Nature | Volume | 390 |
| Issue | 6655 | Pages | 45-51 |
| PubMed ID | 9363890 | Mgi Jnum | J:44109 |
| Mgi Id | MGI:1099360 | Doi | 10.1038/36285 |
| Citation | Kuro-o M, et al. (1997) Mutation of the mouse klotho gene leads to a syndrome resembling ageing [see comments]. Nature 390(6655):45-51 |
| abstractText | A new gene, termed klotho, has been identified that is involved in the suppression of several ageing phenotypes. A defect in klotho gene expression in the mouse results in a syndrome that resembles human ageing, including a short lifespan, infertility, arteriosclerosis, skin atrophy, osteoporosis and emphysema. The gene encodes a membrane protein that shares sequence similarity with the beta-glucosidase enzymes. The klotho gene product may function as part of a signalling pathway that regulates ageing in vivo and morbidity in age-related diseases. |
