| First Author | Kurosu H | Year | 2005 |
| Journal | Science | Volume | 309 |
| Issue | 5742 | Pages | 1829-33 |
| PubMed ID | 16123266 | Mgi Jnum | J:101199 |
| Mgi Id | MGI:3603104 | Doi | 10.1126/science.1112766 |
| Citation | Kurosu H, et al. (2005) Suppression of aging in mice by the hormone Klotho. Science 309(5742):1829-33 |
| abstractText | A defect in Klotho gene expression in mice accelerates the degeneration of multiple age-sensitive traits. Here, we show that overexpression of Klotho in mice extends life span. Klotho protein functions as a circulating hormone that binds to a cell-surface receptor and represses intracellular signals of insulin and insulin-like growth factor 1 (IGF1), an evolutionarily conserved mechanism for extending life span. Alleviation of aging-like phenotypes in Klotho-deficient mice was observed by perturbing insulin and IGF1 signaling, suggesting that Klotho-mediated inhibition of insulin and IGF1 signaling contributes to its anti-aging properties. Klotho protein may function as an anti-aging hormone in mammals. |
