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Publication : zhx-1: a novel mouse homeodomain protein containing two zinc-fingers and five homeodomains.

First Author  Barthelemy I Year  1996
Journal  Biochem Biophys Res Commun Volume  224
Issue  3 Pages  870-6
PubMed ID  8713137 Mgi Jnum  J:34494
Mgi Id  MGI:81950 Doi  10.1006/bbrc.1996.1114
Citation  Barthelemy I, et al. (1996) zhx-1: a novel mouse homeodomain protein containing two zinc-fingers and five homeodomains. Biochem Biophys Res Commun 224(3):870-6
abstractText  A cDNA encoding the complete reading frame of a novel homeodomain-containing protein, named zhx-1, has been cloned from a mouse bone marrow stromal cell line. The ORF encodes a protein of 873 amino acids, in which two C2-H2 zinc-fingers and five homeodomains have been identified. These features classify zhx-1 as a member of the ZF class of homeodomain transcription factors, zhx-1 mRNA is widely expressed in adult mouse, although it is preferentially expressed in brain. At least, two homologous mRNAs are present in humans suggesting that zhx-1 is the first member of a novel subclass of homeodomain factors.
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