Primary Identifier | MGI:1924175 | Organism | mouse, laboratory |
Chromosome | 1 | NCBI Gene Number | 76925 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0) Involved in fusion of sperm to egg plasma membrane involved in single fertilization and spermatogenesis. Located in nuclear membrane. Orthologous to human SPATA46 (spermatogenesis associated 46). PHENOTYPE: Mice homozygous for a knock-out allele exhibit reduced male fertility, teratozoospermia characterized by sperm head malformations, and impaired fertilization with lower rates of sperm-egg fusion. [provided by MGI curators] |