| Primary Identifier | MGI:3695275 | Allele Type | Spontaneous |
| Gene | Tlr4 | Inheritance Mode | Recessive |
| Strain of Origin | B6.KB2-Cln8<mnd> | Is Recombinase | false |
| Is Wild Type | false |
| molecularNote | A large ~8kb insertion is present in a region of exon 2 located between nucleotides 205 and 215 of the coding cDNA. The transcript expressed from this allele contains a 167 bp deletion covering sequences in exon 2, and leads to a frameshift mutation and the appearance of a premature stop codon. The predicted protein is expected to be truncated and missing most of the extracellular domain, the transmembrane domian and the cytoplasmic domain. |
