| Primary Identifier | MGI:1916289 | Organism | mouse, laboratory |
| Chromosome | 5 | NCBI Gene Number | 231070 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.0.0) Predicted to enable oxysterol binding activity and protein sequestering activity. Acts upstream of or within several processes, including ear morphogenesis; negative regulation of fat cell differentiation; and negative regulation of lipid biosynthetic process. Predicted to be located in membrane. Predicted to be part of SREBP-SCAP-Insig complex. Predicted to be active in endoplasmic reticulum membrane. Is expressed in several structures, including alimentary system; eye; ganglia; telencephalon ventricular layer; and vibrissa. Orthologous to human INSIG1 (insulin induced gene 1). PHENOTYPE: Mice homozygous for a knock-out allele exhibit decreased body body weight, increased gonadal and subcutaneous fat pad, decreased circulating triglyceride level and abnormal adipocity differentiation. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
