| First Author | Bridgeman A | Year | 2015 |
| Journal | Science | Volume | 349 |
| Issue | 6253 | Pages | 1228-32 |
| PubMed ID | 26229117 | Mgi Jnum | J:263151 |
| Mgi Id | MGI:6161944 | Doi | 10.1126/science.aab3632 |
| Citation | Bridgeman A, et al. (2015) Viruses transfer the antiviral second messenger cGAMP between cells. Science 349(6253):1228-32 |
| abstractText | Cyclic GMP-AMP synthase (cGAS) detects cytosolic DNA during virus infection and induces an antiviral state. cGAS signals by synthesis of a second messenger, cyclic GMP-AMP (cGAMP), which activates stimulator of interferon genes (STING). We show that cGAMP is incorporated into viral particles, including lentivirus and herpesvirus virions, when these are produced in cGAS-expressing cells. Virions transferred cGAMP to newly infected cells and triggered a STING-dependent antiviral program. These effects were independent of exosomes and viral nucleic acids. Our results reveal a way by which a signal for innate immunity is transferred between cells, potentially accelerating and broadening antiviral responses. Moreover, infection of dendritic cells with cGAMP-loaded lentiviruses enhanced their activation. Loading viral vectors with cGAMP therefore holds promise for vaccine development. |
