| First Author | Campos-Neto A | Year | 2001 |
| Journal | Infect Immun | Volume | 69 |
| Issue | 6 | Pages | 4103-8 |
| PubMed ID | 11349082 | Mgi Jnum | J:69544 |
| Mgi Id | MGI:1934795 | Doi | 10.1128/IAI.69.6.4103-4108.2001 |
| Citation | Campos-Neto A, et al. (2001) Protection against Cutaneous Leishmaniasis Induced by Recombinant Antigens in Murine and Nonhuman Primate Models of the Human Disease. Infect Immun 69(6):4103-8 |
| abstractText | Leishmaniasis affects approximately 2 million people each year throughout the world. This high incidence is due in part to the lack of an efficacious vaccine. We present evidence that the recombinant leishmanial antigens LmSTI1 and TSA, which we identified and characterized previously, induce excellent protection in both murine and nonhuman primate (rhesus monkey) models of human cutaneous leishmaniasis. The remarkable protection induced by LmSTI1 and TSA in an animal model that is evolutionarily close to humans qualifies this antigen combination as a promising candidate subunit vaccine against human leishmaniasis. |
