| First Author | Ohno K | Year | 1999 |
| Journal | J Vet Med Sci | Volume | 61 |
| Issue | 11 | Pages | 1241-4 |
| PubMed ID | 10593583 | Mgi Jnum | J:59586 |
| Mgi Id | MGI:1351822 | Doi | 10.1292/jvms.61.1241 |
| Citation | Ohno K, et al. (1999) Cloning of feline cDNA encoding the cytotoxic T lymphocyte-associated antigen 4 (CTLA-4). J Vet Med Sci 61(11):1241-4 |
| abstractText | Cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) is a CD28 homologue which down-modulate T cell responses rather than augment them. To investigate its biological role in feline immune system, we cloned and sequenced full-length feline CTLA-4 (fCTLA-4) cDNA by RT-PCR from pokeweed mitogen stimulated peripheral blood lymphocytes. The fCTLA-4 contains an open reading frame of 669 nucleotides, coding for a polypeptide of 223 amino acids. The predicted fCTLA-4 amino acids sequence shows the homology of 86.6%, 87.0%, and 76.2% with human, bovine, and murine molecules respectively. The hexapeptide motif (MYPPPY) within the extra-cellular domain of CTLA-4 molecule, which is believed to be responsible for interaction with the B7 family members, is completely conserved in all the species. |
