| First Author | Kamei Y | Year | 1996 |
| Journal | Cell | Volume | 85 |
| Issue | 3 | Pages | 403-14 |
| PubMed ID | 8616895 | Mgi Jnum | J:32922 |
| Mgi Id | MGI:80409 | Doi | 10.1016/s0092-8674(00)81118-6 |
| Citation | Kamei Y, et al. (1996) A CBP integrator complex mediates transcriptional activation and AP-1 inhibition by nuclear receptors. Cell 85(3):403-14 |
| abstractText | Nuclear receptors regulate gene expression by direct activation of target genes and inhibition of AP-1. Here we report that, unexpectedly, activation by nuclear receptors requires the actions of CREB-binding protein (CBP) and that inhibition of AP-1 activity is the apparent result of competition for limiting amounts of CBP/p300 in cells. Utilizing distinct domains, CBP directly interacts with the ligand-binding domain of multiple nuclear receptors and with the p160 nuclear receptor coactivators, which upon cloning have proven to be variants of the SRC-1 protein. Because CBP represents a common factor, required in addition to distinct coactivators for function of nuclear receptors, CREB, and AP-1, we suggest that CBP/p300 serves as an integrator of multiple signal transduction pathways within the nucleus. |
