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Publication : Cloning of the mouse gene encoding plasma glutathione peroxidase: organization, sequence and chromosomal localization.

First Author  Schwaab V Year  1995
Journal  Gene Volume  167
Issue  1-2 Pages  25-31
PubMed ID  8566787 Mgi Jnum  J:30647
Mgi Id  MGI:78150 Doi  10.1016/0378-1119(95)00551-x
Citation  Schwaab V, et al. (1995) Cloning of the mouse gene encoding plasma glutathione peroxidase: organization, sequence and chromosomal localization. Gene 167(1-2):25-31
abstractText  Using a reverse transcription coupled to PCR amplification strategy, with degenerated primers localized in highly conserved domains of known glutathione peroxidase (GPX) proteins, we have generated, from mouse epididymal RNA, a cDNA fragment which was subsequently used to isolate a genomic clone encoding mouse plasma GPX (GPX3). GPX3 is a major enzyme in reducing lipid hydroperoxides and hydrogen peroxide in plasma. We confirm here that the mouse epididymis is a new site of expression of GPX3 and report, together with the sequence, the structural analysis and the chromosomal localization of the mouse GPX3 single-copy gene to chromosome 11.
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