| First Author | Ryseck RP | Year | 1992 |
| Journal | Cell Growth Differ | Volume | 3 |
| Issue | 7 | Pages | 443-50 |
| PubMed ID | 1419907 | Mgi Jnum | J:3829 |
| Mgi Id | MGI:52337 | Citation | Ryseck RP, et al. (1992) Identification of an immediate early gene, pghs-B, whose protein product has prostaglandin synthase/cyclooxygenase activity. Cell Growth Differ 3(7):443-50 |
| abstractText | We have characterized a growth factor-inducible gene, pghs-B, isolated by differential screening of a lambda complementary DNA library from RNA of serum-stimulated NIH 3T3 cells which encodes a 604-amino acid protein presenting high similarity with prostaglandin G/H synthase (PGHS). Induction of both pghs-B mRNA and protein is rapid and remains at high levels for several hours. The increase in pghs-B mRNA is mainly due to transcriptional activation of the gene. PGHS-B has been expressed in the baculovirus system and has been demonstrated to be involved in prostaglandin synthesis and to be inhibited by indomethacin, demonstrating that PGHS-B is indeed an enzyme related to PGHS. The pghs-B gene maps to the [1G-1H2] region of the murine genome. |
