Primary Identifier | MGI:6147627 | Allele Type | Targeted |
Attribute String | Null/knockout | Gene | Acvr1b |
Transmission | Germline | Strain of Origin | 129 |
Is Recombinase | false | Is Wild Type | false |
molecularNote | A loxP site was inserted in intron 1 and an FRT-flanked neo cassette and loxP site were inserted in intron 3 via homologous recombination. Flp-mediated recombination removed the selection cassette. Cre-mediated recombination deleted exons 2 and 3, resulting in a frameshift mutation that eliminates protein expression. |