Primary Identifier | MGI:1915023 | Organism | mouse, laboratory |
Chromosome | 7 | NCBI Gene Number | 67773 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.0.0) Enables enzyme binding activity and histone H4K16 acetyltransferase activity. Involved in neurogenesis and positive regulation of DNA-templated transcription. Located in kinetochore and nuclear matrix. Is expressed in several structures, including genitourinary system; hemolymphoid system gland; limb; nervous system; and respiratory system. Orthologous to human KAT8 (lysine acetyltransferase 8). PHENOTYPE: Mice homozygous for a null allele die prior to gastrulation. Mice homozygous for a floxed allele deleted in the brain exhibit prenatal lethality, intraventricular hemorrhage, enlarged lateral ventricles, and abnormal brain vasculature. [provided by MGI curators] |