| First Author | Metcalfe SM | Year | 2005 |
| Journal | FEBS Lett | Volume | 579 |
| Issue | 3 | Pages | 609-14 |
| PubMed ID | 15670816 | Mgi Jnum | J:96167 |
| Mgi Id | MGI:3529633 | Doi | 10.1016/j.febslet.2004.12.027 |
| Citation | Metcalfe SM, et al. (2005) Leukaemia inhibitory factor (LIF) is functionally linked to axotrophin and both LIF and axotrophin are linked to regulatory immune tolerance. FEBS Lett 579(3):609-14 |
| abstractText | Axotrophin (axot) is a newly characterised stem cell gene and mice that lack axotrophin are viable and fertile, but show premature neural degeneration and defective development of the corpus callosum. By comparing axot+/+, axot+/- and axot-/- littermates, we now show that axotrophin is also involved in immune regulation. Both T cell proliferation and T cell-derived leukaemia inhibitory factor (LIF) were suppressed by axotrophin in a gene-dose-dependent manner. Moreover, a role for axotrophin in the feedback regulation of LIF is implicated. This is the first evidence that fate determination mediated by LIF maybe qualified by axotrophin. |
