| First Author | Brown JA | Year | 2002 |
| Journal | Eur J Immunol | Volume | 32 |
| Issue | 6 | Pages | 1764-72 |
| PubMed ID | 12115660 | Mgi Jnum | J:77096 |
| Mgi Id | MGI:2180993 | Doi | 10.1002/1521-4141(200206)32:6<1764::AID-IMMU1764>3.0.CO;2-V |
| Citation | Brown JA, et al. (2002) T helper differentiation in resistant and susceptible B7-deficient mice infected with Leishmania major. Eur J Immunol 32(6):1764-72 |
| abstractText | The contribution of the costimulatory molecules B7-1 and B7-2 to the in vivo differentiation of Th cells remains controversial. The infection of resistant and susceptible strains of mice with the parasite Leishmania major provides a well-established model for studying in vivo differentiation of CD4+ T cells. We have infected B7-1/B7-2-deficient mice on the BALB/c and 129 background with L. major and subsequently examined different parameters of infection and cytokine responses upon restimulation of lymph node cells in vitro. BALB/c B7-2-deficient and B7-1/B7-2-double deficient mice are resistant to L. major, whereas BALB/c B7-1-deficient mice remain as susceptible as wild-type BALB/c mice. Differential expression of B7-1 and B7-2 can explain the distinct roles observed for these B7 costimulators in L. major infection. |
