|  Help  |  About  |  Contact Us

Publication : A unique B2 B cell subset in the intestine.

First Author  Shimomura Y Year  2008
Journal  J Exp Med Volume  205
Issue  6 Pages  1343-55
PubMed ID  18519649 Mgi Jnum  J:137039
Mgi Id  MGI:3797677 Doi  10.1084/jem.20071572
Citation  Shimomura Y, et al. (2008) A unique B2 B cell subset in the intestine. J Exp Med 205(6):1343-55
abstractText  Over 80% of the body's activated B cells are located in mucosal sites, including the intestine. The intestine contains IgM(+) B cells, but these cells have not been characterized phenotypically or in terms of their developmental origins. We describe a previously unidentified and unique subset of immunoglobulin M(+) B cells that present with an AA4.1(-)CD21(-)CD23(-) major histocompatibility complex class II(bright) surface phenotype and are characterized by a low frequency of somatic hypermutation and the potential ability to produce interleukin-12p70. This B cell subset resides within the normal mucosa of the large intestine and expands in response to inflammation. Some of these intestinal B cells originate from the AA4.1(+) immature B2 cell pool in the steady state and are also recruited from the recirculating naive B cell pool in the context of intestinal inflammation. They develop in an antigen-independent and BAFF-dependent manner in the absence of T cell help. Expansion of these cells can be induced in the absence of the spleen and gut-associated lymphoid tissues. These results describe the existence of an alternative pathway of B cell maturation in the periphery that gives rise to a tissue-specific B cell subset.
Quick Links:
 
Quick Links:
 

Expression

Publication --> Expression annotations

 

Other

28 Bio Entities

Trail: Publication

0 Expression