| First Author | Stanton LW | Year | 1983 |
| Journal | Nature | Volume | 303 |
| Issue | 5916 | Pages | 401-6 |
| PubMed ID | 6304522 | Mgi Jnum | J:7074 |
| Mgi Id | MGI:55545 | Doi | 10.1038/303401a0 |
| Citation | Stanton LW, et al. (1983) Translocation, breakage and truncated transcripts of c-myc oncogene in murine plasmacytomas. Nature 303(5916):401-6 |
| abstractText | Comparative nucleotide sequence analysis of a rearranged c-myc gene in a murine plasmacytoma and c-myc cDNA from normal spleen reveals that chromosomal translocation in the plasmacytoma breaks the c-myc gene within the first exon or intron. In the plasmacytoma truncated c-myc RNAs initiate from newly exposed promoter sites. Nevertheless, the myc polypeptide produced in the plasmacytoma is probably the same as that from the intact c-myc gene because the exon lost by breakage and translocation is non-coding. The second and third exons of the mouse c-myc gene are substantially conserved in the v-myc gene of the avian retrovirus, MC29. |
