| First Author | Clayton LK | Year | 1987 |
| Journal | Eur J Immunol | Volume | 17 |
| Issue | 9 | Pages | 1367-70 |
| PubMed ID | 2820751 | Mgi Jnum | J:8841 |
| Mgi Id | MGI:57306 | Doi | 10.1002/eji.1830170922 |
| Citation | Clayton LK, et al. (1987) Murine and human T11 (CD2) cDNA sequences suggest a common signal transduction mechanism. Eur J Immunol 17(9):1367-70 |
| abstractText | The murine equivalent of the cDNA encoding the human T11 (CD2) sheep erythrocyte-binding protein has been cloned. It codes for a putative transmembrane protein which is homologous to human T11. In contrast to immunoglobulins whose domains consist of anti-parallel beta sheets, we predict that mouse and human T11 external domains probably belong to the alpha/beta protein folding class. The cytoplasmic region of T11 is a lengthy, proline-rich segment; secondary structural analysis predicts it to have a nonglobular conformation. This elongated tail could allow for interaction with multiple other intracellular proteins and may contain a cation-binding site involved in T lineage activation. |
