| First Author | Morioka S | Year | 2017 |
| Journal | Exp Cell Res | Volume | 357 |
| Issue | 2 | Pages | 252-259 |
| PubMed ID | 28552585 | Mgi Jnum | J:260958 |
| Mgi Id | MGI:6151758 | Doi | 10.1016/j.yexcr.2017.05.022 |
| Citation | Morioka S, et al. (2017) Phosphoinositide phosphatase Sac3 regulates the cell surface expression of scavenger receptor A and formation of lipid droplets in macrophages. Exp Cell Res 357(2):252-259 |
| abstractText | The findings of this study suggest that the phosphoinositide phosphatase Sac3 maintains the protein level of scavenger receptor A (SR-A) and regulates foam cell formation. RAW264.7 macrophages were transfected with short hairpin RNAs that target Sac3. The knockdown decreased the level of the cell surface SR-A and suppressed the acetylated low density lipoprotein-induced foam cell formation. The associated regulator of PIKfyve (ArPIKfyve) is a scaffold protein that protects Sac3 from proteasome-dependent degradation. The knockdown of ArPIKfyve decreased Sac3, cell surface SR-A, and foam cell formation. The knockdown of PIKfyve had no effect on SR-A protein levels. These results suggest that the ArPIKfyve-Sac3 complex regulates SR-A protein levels independently of its effect on PIKfyve activity. |
