| First Author | Chruscinski AJ | Year | 1992 |
| Journal | Biochem Biophys Res Commun | Volume | 186 |
| Issue | 3 | Pages | 1280-7 |
| PubMed ID | 1354956 | Mgi Jnum | J:2037 |
| Mgi Id | MGI:50561 | Doi | 10.1016/s0006-291x(05)81544-x |
| Citation | Chruscinski AJ, et al. (1992) Cloning and expression of the mouse homolog of the human alpha 2-C2 adrenergic receptor. Biochem Biophys Res Commun 186(3):1280-7 |
| abstractText | Three subtypes of alpha 2 adrenergic receptors have been identified in the human and rat. The subtype located on human chromosome 2 (alpha 2-C2) is unique in that it is expressed mainly in the peripheral tissues and lacks sites for N-linked glycosylation. We isolated the gene encoding the mouse homolog of the human alpha 2-C2 adrenergic receptor (M alpha 2-2H). The deduced amino acid sequence of the M alpha 2-2H shows 82% and 96% identity to the human alpha 2-C2 and the rat RNG alpha 2 adrenergic receptors, respectively. Southern blot analysis demonstrated that the M alpha 2-2H was encoded by a single copy gene and was distinct from the mouse homologs of the alpha 2-C4 and alpha 2-C10 adrenergic receptors. When expressed in COS-7 cells, the M alpha 2-2H exhibited a pharmacological profile similar to the human alpha 2-C2 and rat RNG alpha 2 receptors. |
