| First Author | Seyfarth K | Year | 2015 |
| Journal | J Nutr Biochem | Volume | 26 |
| Issue | 1 | Pages | 75-81 |
| PubMed ID | 25448609 | Mgi Jnum | J:225699 |
| Mgi Id | MGI:5694037 | Doi | 10.1016/j.jnutbio.2014.09.002 |
| Citation | Seyfarth K, et al. (2015) The development of diet-induced obesity and associated metabolic impairments in Dj-1 deficient mice. J Nutr Biochem 26(1):75-81 |
| abstractText | DJ-1 constitutes a ubiquitously expressed, oxidative stress-responsive protein with multiple functions. DJ-1 emerged as a candidate from our previous proteome analysis investigating alterations in the hypothalamus in three mouse strains differing in their susceptibility to diet-induced obesity (DIO). Validation studies demonstrated a high-fat diet (HFD)-induced shift in the DJ-1 isoform pattern in the hypothalamus and several other tissues of mice. Others found HFD-induced alterations in DJ-1 protein abundance in adipose tissue and pancreatic islets in wild-type rodents. Here, we investigated the gene-diet interaction by challenging Dj-1(-/-) mice with a HFD. We demonstrate that the development of diet-induced obesity (DIO) Dj-1(-/-) mice is according to wild-type mice with the exception of transient higher gains in fat mass at the expense of lean mass after 14 weeks of feeding. |
