| Primary Identifier | IPR002014 | Type | Domain |
| Short Name | VHS_dom |
| description | The VHS domain is an about 150 residues long domain, whose name is derivedfrom its occurrence in VPS-27, Hrs and STAM. The VHS domain is found at the N-termini of proteins associated with endocytocis and/or vesicular trafficking,often in association with other domains like FYVE, SH3 or TAM [, ]. The VHS domain of Hrs makes both intra- andintermolecular interactions with FYVE domains and it has been proposed that itmight as well interact with other domains. The VHS domain might function as amultipurpose docking adapter that localizes proteins to the membrane throughinteractions with the membrane and/or the endocytic machinery [, ].Resolution of the crystal structure of the VHS domain of Drosophila Hrs andhuman Tom1 revealed that it consists of eight helices arranged in a superhelix[, ]. |
