| First Author | Deruytter N | Year | 2004 |
| Journal | Diabetes | Volume | 53 |
| Issue | 12 | Pages | 3323-7 |
| PubMed ID | 15561967 | Mgi Jnum | J:94603 |
| Mgi Id | MGI:3513582 | Doi | 10.2337/diabetes.53.12.3323 |
| Citation | Deruytter N, et al. (2004) Mapping non-class II H2-linked loci for type 1 diabetes in nonobese diabetic mice. Diabetes 53(12):3323-7 |
| abstractText | Major histocompatibility complex (MHC) plays a largely predominant role in the genetic predisposition to type 1 diabetes, in both humans and rodents. While class II loci have long been recognized as essential, they do not fully explain the MHC-linked genetic component of type 1 diabetes. In the present study, using new NOD congenic strains harboring defined chromosomal segments from C57BL/6 mice, we circumscribed three distinct loci influencing murine type 1 diabetes and tightly linked to but separated from the class II region. Our findings might guide the search for additional HLA-linked loci in human type 1 diabetes. |
